Investigation of Production Process and GC-MS Analysis of Chemical Constituents of Three Traditional Medicines Sumbawa Oils
Keywords:
Sumbawa oil, traditional medicine, GC-MS analysisAbstract
The aims of this research are to study the production process and the chemical composition of three traditional Sumbawa oils from Benete Village (BT), Batu Dulang Village (BD), and Hutan Sumbawa (HS). A survey was conducted to learn the production process and the chemical composition of the Sumbawa oils was determined by fractionation method using three solvents with different polarity (methanol, dichloromethane (DCM) and n-hexane), followed by GC-MS analysis of each extract. In general, the three Sumbawa Oils were traditionally produced by mixing various species of medical plants into the coconut oil through heating process. Based on GC-MS analysis, the constituents of the Sumbawa oils are mainly fatty acid, fatty acid ester, monoterpene and sesquiterpene. Three major identical compounds were identified in all three products with different percentages of abundance namely Octadecanoic acid/stearic acid, Hexadecanoic acid/palmitic acid, and methyl palmitate. Furthermore, there were other major compounds such as Linoleic acid, Lycopersene, and Dodecanoic acid/lauric acid. The non-natural product compounds found in Sumbawa oil extracts and the biological activities of major compounds are discussed in this article.
Downloads
References
[1]. Ijaola TO, Osunkiyesi AA, Taiwo AA, Oseni OA, Lanreiyanda Y, Ajayi JO, et al., IOSR J Appl Chem., 2014, 7(5), 16-25.
[2]. Sarma DSK, Babu AVS, Krishna KR, Basha PPN. J Chem Pharm Res., 2011, 3(4),875-881.
[3]. Svoboda KP, Gough J, Hampson J, Galambosi B., Flav Fragr J., 1995, 10, 139-145.
[4]. Sampaiao BL, Edrada-Ebel R, Costa FBD, Sci Rep, 2016, 6, 29265.
[5]. Warner K, Chemistry of frying oils, In: Akoh CC, Min DB, editors, Food lipids chemistry, nutrition, and biotechnology, 2002, CRC Press Inc., USA.
[6]. Pan KL, Huang WJ, Hsu MH, Lee HL, Liu HJ, Chenge CW, et al., Chem Res Toxicol., 2014, 27(10), 1707-1719.
[7]. Nouspikel N., CHEBI:77619 - 1,3-dipalmitoylglycerol, http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:77619. 20 February 2017.
[8]. ChEBI Team, CHEBI:75568 - 1-monolinolein, https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:75568. 20 February 2017.
[9]. Harada H, Yamashita U, Kurihara H, Fukushi E, Kawabata J, Kamei Y., Anticancer Res., 2002, 22, 2587-2590.
[10]. Sermakkani M, Thangapandian V., Asian J Pharm Clin Res., 2012, 5(2), 90-94.
[11]. Semary NA, Ghazy SM, Naby MM., Aust J Basic & Appl Sci., 2009, 3, 1540−1551.
[12]. Ahmad Z, Zamhuri KF, Yaacob A, Siong HC, Selvarajah M, Ismail A, et al., Molecules, 2012, 17(8), 9631-9640.
[13]. Melariri P, Campbell W, Etusim P, Smith P., Adv Stud Biol., 2012, 4(3), 333-349.
[14]. Abascal K, Yarnell E., Focus Altern Complement Ther., 2014, 20(2), 91-95.
[15]. Dayrit, FM., J Am Oil Chem Soc., 2015, 92(1), 1-15.
[16]. Lee H, Woo JP., J Med Food, 2014, 17(2), 189-197.
[17]. Gerhard N., Dictionary of pharmaceutical medicine, 2009, Springer Wien New York, Germany.
[18]. Shilling M, Matt L, Rubin E, Visitacion MP, Haller NA, Grey SF, et al., J Med Food, 2013, 16(12), 1079-1085.
[19]. Wang YN, Wang HX, Shen ZJ, Zhao LL, Clarke SR, Sun JH, et al., J Econ Entomol, 2009, 102(1), 196-202.
[20]. McGaw LJ, Jäger AK, Staden JV., Fitoterapia, 2002, 73,431-433.
[21]. Wang ZJ, Liang CL, Li GM, Yu CY, Yin M., Acta Pharmacol Sin., 2007, 28(3), 315-326.
[22]. Beytia ED, Qureshi AA, Porter JW., J Biol Chem., 1973, 248, 1856-1867.
[23]. Francis JB, Asaf AO, Erich JS, John WP., J Biol Chem., 1972, 218(8), 2768-2773.
[24]. Jacintha TMA, Sarvana GA, Uthayakumari F, Santhana M., World J Pharm Res., 2016, 5(12), 1333-1340.
[25]. Cai P, Kaphalia BS, Ansari GA., Toxicology, 2005, 210, 197-204.
[26]. Lin HW, Liu CZ, Cao D, Chen PY, Chen MF, Lin SZ, et al., Proc Natl Acad Sci USA, 2009, 105, 19526-19531.
[27]. Sarkar S, Khan MF, Kaphalia BS, Ansari GA., J Biochem Mol Toxicol, 2006, 20, 302-308.
[28]. Wang YN, Wang HX, Jin YS, Bu CY, Cheng J, Zhao LL, et al., J Econ Entomol, 2010, 103, 1372-1377.
Downloads
Published
Issue
Section
License
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).