Effect of Topical Aplication of Gel Aloe Vera Extract on The UVB-Induced Skin Photoaging in Hairless Rats

Authors

  • Izzatul Lailiyah Brawijaya University
  • Sasangka Prasetyawan Brawijaya University
  • Aulanni'am Aulanni'am Brawijaya University

DOI:

https://doi.org/10.21776/ub.jpacr.2017.006.02.321

Keywords:

Photoaging, Aloe vera, Malondialdehyde (MDA), AP-1, SOD

Abstract

UVB generates the production of Reactive Oxygen Species (ROS) and decrease antioxidants enzymatic excessively. Both of these biological effects caused photo-aging. Excessive ROS production afforded overexpression of AP-1 as a major regulator of photoaging. This paper figured out the potential of Aloe vera extract as topical gel treatment on the UVB-induced skin photo-aging in twenty male wistar hairless rats (Rattus novergicus) divided into 2 groups. First group was induced by UVB and the second was induced by UVB and topical gel extract Aloe vera treatment. Each group was given treatment for 4 weeks. The expression of MDA and SOD were measured with immunohistochemistry. The result showed that the topical gel therapy decreased the MDA expression and increased SOD expression significantly (p < 0.01). The conclusion from this study was Aloe vera extract had potentially as an alternative topical treatment of photoaging.

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Author Biographies

  • Izzatul Lailiyah, Brawijaya University
    Jurusan Kimia Fakultas MIPA Universitas BrawijayaJl. Veteran 65145 Malang
  • Sasangka Prasetyawan, Brawijaya University
    Jurusan Kimia Fakultas MIPA Universitas BrawijayaJl. Veteran 65145 Malang
  • Aulanni'am Aulanni'am, Brawijaya University

    Fakultas Kedokteran Hewan dan Jurusan Kimia Fakultas MIPA Universitas Brawijaya

    Jl. Veteran 65145 Malang

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Published

2017-05-06

How to Cite

Effect of Topical Aplication of Gel Aloe Vera Extract on The UVB-Induced Skin Photoaging in Hairless Rats. (2017). The Journal of Pure and Applied Chemistry Research, 6(2), 112-116. https://doi.org/10.21776/ub.jpacr.2017.006.02.321