Effect of Topical Aplication of Gel Aloe Vera Extract on The UVB-Induced Skin Photoaging in Hairless Rats
Izzatul Lailiyah, Sasangka Prasetyawan, Aulanni'am Aulanni'am
J. Pure App. Chem. Res. Vol 6, No 2 (2017), pp. 112-116
Submitted: January 25, 2017     Accepted: April 11, 2017     Published: May 06, 2017
DOI: http://dx.doi.org/10.21776/ub.jpacr.2017.006.02.321

Abstract


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UVB generates the production of Reactive Oxygen Species (ROS) and decrease antioxidants enzymatic excessively. Both of these biological effects caused photo-aging. Excessive ROS production afforded overexpression of AP-1 as a major regulator of photoaging. This paper figured out the potential of Aloe vera extract as topical gel treatment on the UVB-induced skin photo-aging in twenty male wistar hairless rats (Rattus novergicus) divided into 2 groups. First group was induced by UVB and the second was induced by UVB and topical gel extract Aloe vera treatment. Each group was given treatment for 4 weeks. The expression of MDA and SOD were measured with immunohistochemistry. The result showed that the topical gel therapy decreased the MDA expression and increased SOD expression significantly (p < 0.01). The conclusion from this study was Aloe vera extract had potentially as an alternative topical treatment of photoaging.

Keywords : Photoaging, Aloe vera, Malondialdehyde (MDA), AP-1, SOD
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References


[1] D’Orazio, J., S. Jarret, A. Amaro-Ortiz, T. Scott. Int. J. Mol. Sci, 2013, 14, 12222-12248.
[2] Ichihashi, M., H. Ando, M. Yoshida, Y. Niki, M. Matsui, JAAM, 2009, 6(6), 46-59.
[3] Svobodova, A., D. Walterova, J. Vostalova, Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 2006, 150(1), 25-38.

[4] Fisher, G. J., Z. Q. Wang, S. C. Datta, J. Varani, S. Kang, J. J. Voorhees, NEJM, 1997, 337(20), 1419-1428.
[5] Feng, X. X., X. T.Yu, W. J. Li, S. Z. Kong, Y. H. Liu, X. Zhang, Y. F. Xian, X. J. Zhang, Z. R. Su, Z. X. Lin, Eur. J. Pharm. Sci., 2014, 63, 113-123.
[6] Janero, D. R., Free Radical Biol Med, 1990, 9(6), 515-540.
[7] Qadir, M. I., Int J Nat Ther, 2009, 2, 21-26.
[8] R. Rajeswari, M. Umadevi, C. S. Rahale, R. Pushpa, S. Selvavenkadesh, K. P. S. Kumar, D. Bhowmik, J Pharmacogn Phytochem, 2012, 1(4), 118-124.
[9] Sahu, P. K., D. D Giri, R. Singh, P. Pandey, S. Gupta, A. K Shrivastava, A. Kumar, K. D Pandey, Pharmacol Pharm, 2013, 4, 599-610.
[10] Pandel, R., B. Poljšak, A. Godic, R. Dahmane, ISRN Dermatol., 2013, 2013, 1-11.
[11] Wenk, J., P. Brenneisen, C. Meewes, M. Wlaschek, T. Peters, R. Blaudschun, W.Ma, L. Kuhr, L. Schneider, K. Scharffetter-Kochanek, Curr Probl Dermatol, 2001, 29, 83-94.


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