Characterization Of Alkaloids From The Leaves Of Psychotria Malayana Jack Of Lombok Island On The Basis Of Gas Chromatography-Mass Spectroscopy
Surya Hadi, Khairul Pahmi Rahmawati, Dina Asnawati, Vera Fitriya Ersalena, Ahmadun Azwari
J. Pure App. Chem. Res. Vol 3, No 3 (2014), pp. 108-113
Submitted: February 22, 2014     Accepted: April 30, 2014     Published: June 07, 2014

Abstract


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The genus Psychotria is well known as a source of alkaloids and has contributed several novel indole-type alkaloids with quite a broad spectrum of bioactivities. This study was focused on identifying the alkaloids from the leaves of P. malayana Jack from Lombok island on the basis of Gas Chromatography-Mass Spectroscopy (GC-MS) data and the sample preparation followed acid-base extraction. The study showed that the major alkaloid contained by the leaves was hodgkinsine and other minor compounds, namely calycanthine, chimonantine, 2-ethyl-6-methylpyrazine, and 3-methyl-1,2,3,4-tetrahydro-gamma-carboline. Bioactivities of the compounds were also discussed.


Keywords : alkaloids, Psychotria malayana, Lombok
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References


Yohannes Shin Kasahara, Medicinal Herb Index in Indonesia, 1985, P.T. Eisai Indonesia. [2] Frescura, Viviane Dal-Souto, Andrielle Wouters Kuhn, H. D. Laughing House IV; Jucara Terezinha Paranhos; Solange Bosio Tedesco, J. Biocell., 2013, 37, 23-28. [3] Hadi, S. and Bremner J.B., Molecules. 2001, 6, 117-129. [4] Hart, N. K.; Johns, S. R.; Lamberton, J. A.; Summons, R. E., Aust. J. Chem. 1974, 27, 639-646. [5] Hodson, H. F.; Robinson, B.; Smith, G. F. Proc. Chem. Soc. London, 1961, 465. 7. [6] (a) Grant, I. J.; Hamor, T. A.; Robertson, J.M.; Sim, G. A. Proc. Chem. Soc., London, 1962, 148; (b) Grant, I. J.; Hamor, T. A.; Robertson, J. M.; Sim, G. A. J. Chem. Soc. 1965 , 5678. [7] Verotta, L.; Peterlongo, F.; Elisabetsky, E.; Amador, T.A; Nunes, D.S., J. Chromatogr. A, 1999, 841, 165-176. [8] Verotta, L.; Orsini, F.; Sbacchi, M.; Scheildler, M. A.; Amador, T.A.; Elisabetsky, E. Bioorg. Med. Chem., 2002, 10, 2133-2142. [9] Amador, T.A.; Verotta, L.; Nunes, D.S.; Elisabetsky, E. Phytomedicine, 2001, 8 (3), 202-206. [10] Manske, R.H.F.;Editor The Alkaloids Vol. 8: The Indole Alkaloids,1965, 861 [11] Hadi, S., Bioactive Alkaloids From Medicinal Plants Of Lombok, 2002; Department of Chemmistry, The University of Wollongong, Australia. [12] Chebib, Mary; K. Duke, Rujee; Duke, Colin C. ; Connor, Mark; N. Mewett, Kenneth and A.R. Johnston, Graham. Toxicol. App. Pharmacol., 2003, 190, 58–64. [13] Anet, E. F. L. J.; Hughes, G. K.; Ritchie, E. Aust. J. Chem., 1961, 14, 173-174. [14] Fridrichsons, J.; Mackay, M. F.; Mathieson, A. M., Tetrahedron, 1974, 30, 85-92. [15] Hendrickson, J. B.; Goeschke, R.; Rees, R. Tetrahedron, 1964, 20, 565-579. [16] Kodanko, J. J.; Hiebert, S.; Peterson, E. A.; Sung, L.; Overman, L. E.; Linck, V. M.; Goerck, G. C.; Amador, T. A.; Leal, M. B.; Elisabetsky, E. J. Org. Chem., 2007, 72 (21), 7909-7914. [17] Amador, T. A.; Verotta, L.; Nunes, D. S.; Elisabetsky, E. Planta Med., 2000, 66, 770- 772. [18] Seetharamanjaneya S P, Raghavan K V, Rao P. K. and Kulkarni S. J., 2002 US 143180 A1 [19] Forni L, Stern G and Gatti M., Appl. Catal., 1987, 29, 16. [20] Murray KE, and Whitfield FB., J. Sci. Food Agric., 1975, 26, 973-986. [21] Wang, Da-Hong and Wen-Yi Tao. A., J. Microbiol. Res., 2009, 3, 755-760. [22] Cao, Rihui; Peng, Wenlie; Wang, Zihou and Xu, Anlong., Curr. Med. Chem., 2007, 14, 479-500.


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