The Effect of Rice Bran Cereals on Total Cholesterol, Malondialdehyde (MDA) Levels and Histopathology Description of Aortic Organ on Mice Model of Hypercholesterolemia
Dolly Irnawati Neno, Chanif Mahdi, Sasangka Prasetyawan
J. Pure App. Chem. Res. Vol 7, No 3 (2018), pp.
Submitted: July 03, 2018     Accepted: September 20, 2018     Published: November 22, 2018

Abstract


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Hypercholesterol is a metabolic disorder effect of the high cholesterol levels in the body beyond the normal limits. Hypercholesterolemia can cause various generative diseases such as atherosclerosis, coronary heart disease and hypertension. Rice bran cereal is known to have the potential to lower cholesterol levels in the blood. The fiber content in rice bran cereals can bind cholesterol in the body and secrete it through the feces while tocopherol as an antioxidant that stops the lipid peroxidation process and reduces oxidative stress. The aims of this study were to determine the role of rice bran cereals to decreased total cholesterol and malondialdehyde levels cause of hypercholesterolemia. This study used rats white Rattus Norvegicus as animals test which was divided into 5 groups: control group (healthy rats), hypercholesterolemia group (sick rat) and 3 therapy groups with variation dose respectively 270, 540 and 810 mg/kg BB. Data analysis for total cholesterol and malondialdehyde levels used oneway anova α = 0.05 with tukey as follow-up test. The results of statistical analysis prove that rice bran cereal with a dose of 810 mg/kg body weight can affect for the changes of total cholesterol and malondialdehyde levels that is 21.72% and 50.88%. The results showed that rice bran cereals therapy could significantly influence (p = 0.05) to decrease total cholesterol and malondialdehyde levels in hypercholesterolemic rats.



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