Synthesis and Characterization of Fe3O4 Nanoparticles Modified with Polyethylene Glycol as Antibacterial Material
Poedji Loekitowati Hariani, Desnelli Desnelli, Fatma Fatma, Rizki Indah Putri, Salni Salni
J. Pure App. Chem. Res. Vol 7, No 2 (2018), pp.
Submitted: November 24, 2017     Accepted: February 23, 2018     Published: May 07, 2018


Cover Image

The iron oxide (Fe3O4) nanoparticles modified with polyethylene glycol (PEG) was synthesized by co-precipitation methods using ferric and ferrous ions as the precursors. Further, the antibacterial activity was performed against gram-positive and gram-negative bacteria. The Fe3O4-PEG was characterized using X-Ray Diffraction (XRD), Fourier Transform Infra Red (FTIR), Scanning Electron Microscopy (SEM) with energy dispersive X-Ray analysis (EDAX) and Vibrating Sample Magnetometer (VSM). The particle size of Fe3O4-PEG calculated using XRD is 46.2 nm. The study confirmed that Fe3O4-PEG is superparamagnetic and has a saturation magnetization of 56.43 emu/g. The prepared Fe3O4-PEG gives the effect of both gram-positive and gram-negative pathogenic bacterial strains hence this material has potential utilization in the field of pharmaceutical and biomedical in the future.


Keywords : Fe3O4, nanoparticle, PEG, antibacterial activity
Full Text: PDF


[1] Sharma, Y.C., and Srivastava, V., J. Chem. Eng. Data, 2011, 56, 819–825.

[2] Shahriari, T., Bidhendi, G.B., Mehrdadi, N., Int. J. Environ. Sci. Technol., 2014, 11, 349–356.

[3] Sam, S., and Nesaraj, A.S., Int. J. Appl. Sci. Eng., 2011, 9(4), 223–239.

[4] Prabhu, Y. T., and Rao, K, V., Int. Nano Lett., 2015, 5, 85–92.

[5] Vignesh, R. H., Sankar, K.V., Amaresh, S., Lee, Y.S., Selvan, R.K., Sensor Actuat B-Chem., 2015, 220, 50–58.

[6] Iwasaki, T., Mizutani, N., Watano, S., Yanagida, T., Kawai, T., J. Exp. Nano Sci., 2010, 5(3), 251–262.

[7] Chen, F., Xie, S., Zhang, J., Liu, R., Materials Letters, 2013, 112, 177–179.

[8] Lei, W., Liu, Y., Si, X., Xu, J., Du, W., Yang, J., Zhou, T., Lin, J., Phys. Lett. A, 2016, 8(16), 1–5.

[9] Zhou, Z. H., Wang, J., Liu, X., Chan, H. S. O., J. Mater. Chem., 2001, 11, 1709–1711.

[10] Es’haghzade, Z., Pajootan, E., Bahrami, H., Arami, M., J. Taiwan Inst. Chem. Eng., 2016, 9(54), 1–15.

[11] Karimzadeh, I., Aghazadeh, M., Doroudi, T., Ganjali, M. R., Kolivand, P. H., Advances in Physical Chemistry, 2017, 1–8.

[12] Shanmugavel, T., Raj, S. G., Kumar, G. R., Rajarajan, G., Phys. Procedia, 2014, 54, 159–163.

[13] Sharafi, A., and Seyedsadjadi, M., Int. J. Bio-Inorg. Hybd. Nanomat., 2013, 2(3), 437–441.

[14] Behera, S.S., Patra, J.K., Pramanik, K., Panda, N., Thatoi, H., World J. Nano Sci. Eng., 2012, 2, 196–200.

[15] Shahzeidi, Z. S., and Amiri, Gh., Int. J. Bio-Inorg. Hybd. Nanomat., 2015, 4(3), 135–140.

[16] Topkaya, R., Kurtan, U., Baykal, A., Sozeri, K., Toprak, M. S., J. Inorg Organomet Polym., 2013, 23, 592–598.

[17] Junejo, Y., Baykal, A., Sozeri, H., Cent. Eur. J. Chem., 2013, 11(9), 1527–1532.

[18] Tamhakar, P.M., Kulkarni, A.M., Watawe, S.C., Mater. Sci. App., 2011, 2, 1317–1321.

[19] Zheng, X. F., and Lian, Q., J. Disper. Sci. Technol., 2015, 36, 245–251.

[20] Mukhopadhyay, A., Joshi, N., Chattopadhyay, K., De, G., ACS Appl. Mater. Interfaces., 2012, 4, 142–149.

[21] Hariani, P. L., Faizal, M., Ridwan, Marsi, Setiabudidaya, D., Int. J. Env. Sci. Dev., 2013, 4(3), 336–340.

[22] Zhu, H. Y., Fu, Y. Q., Jiang, R., Jiang, J. H., Xiao, L., Zeng, G. M., Zhao, S.L., Wang, L., Chem. Eng. J., 2011, 173, 494 – 502.

[23] Paredes, D., Ortiz, C., Torres, Int. J. Nanomed., 2014, 9, 1717–1729.

[24] Sulanjari., Santi, W. N., Artanti, A. A., Suharyadi, E., Kato, E., Iwata, S., JFI, 2014, 54, XVIII, 103–107.

[25] Wei, Y., Han, B., Hu, X., Lin, Y., Wang, X., Deng, X., Procedia Engineering, 2012, 27, 632 – 637.

[26] Reddy, D. H. K., and Yun, Y. S., Coord. Chem. Rev., 2016, 315, 90 – 111.

[27] Atmaca, S., Gul, K., Cicek., R., Tr. J. of Medical Science, 1998, 28, 595 – 597.

[28] Sanpo, N., Wen, C., Berndt, C., Wang, J., Antibacterial Properties of Spinel Ferrite Nanoparticles in Microbacterial pathogens and strategies for combating them: science, technology and education, 2013, Formatex Research Center, Spain.

[29] Nalawade, T.M., Bhat, K.,Sogi, S. H. P., J. Int. Soc. Prev. Comm. Dent., 2015, 5(2), 114–119.


  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.